Wyoming is a city in Kent County in the U.S. state of Michigan. The population was 76,501 at the 2020 census. Wyoming is the second …Wyoming is a city in Kent County in the U.S. state of Michigan. The population was 76,501 at the 2020 census. Wyoming is the second most-populated community in the Grand Rapids metropolitan area and is bordered by Grand Rapids on the northeast. After Grand Rapids, it is also the second most-populated city in West Michigan.